Embrace of the Serpent tells the epic story of the first contact, encounter, approach, betrayal and, eventually, life-transcending friendship, between Karamakate, an amazonian shaman, last survivor of his people, and two scientists that, over the course of 40 years, become the first men to travel the Northwest Amazon in search of ancestral knowledge. Inspired by the journals of the first explorers of the Colombian Amazon, German ethnologist Theodor Koch-Grunberg and American botanist Richard Evans Schultes.